as i understand it, isolating noise is directly related to your ability to dampen the vibration that transfers it.
structural integrity plays a role here. we haven't heard how the home is built but, for example, an older hardwood floor that has gotten creeky and loose over the years will have enough play in it to freely transfer vibrations associated with noise.
make sure all your subfloors, joist, wall surfaces, rafters, everything are tight. use heavy floor covers and have your home owner consider heavy wall furnishings and drapes.
i'll keep saying it, but automotive technologies can be of some use to you here. visit quietcar.com for products that will help you insulate small, hard to reach or stangely shaped areas such as the inside of electrical boxes, hvac ducts etc. etc.....
if you look at most condo or apartments being built today, they use wall structures seperating the units that do not touch each other. that should tell you something.
keep us informed of your progress! good luck!