Yes. They make R-15 fiberglass insulation for 2x4 walls. I think the other responses are a little overboard...I don't imagine you plan on removing the wall and rebuilding it using an insanely different material.In a 2x4 wall in the northeast, R13 is recommended..however, R15 is the same exact depth ( 3 1/2"). Can you then use the R15 fiberglass insulation because the depth is the same and technically wont be any more compressed?