Since you are familier with computers what you need is a system set up you can control through your computer; from home or wherever.
Blocking off vents can build up pressure in your duct system. If there is no way to relieve this extra pressure your system will be damaged and operate inefficiently. If a zoning system is designed a pressure relief bypass duct can be installed to help with this problem.
Duct boosters rarely deliver the desired results and IMO are a waste of time and money.
Don't forget the most important part of the job - keeping out the dirt. Dirt is the enemy of your system and without good air filtering all your work will be in vain. I inspect/tear out failed systems everyday that are packed with mother earth. Without air filter neglect hvac contractors would have no work
Your first step is knowing how much heat you need to get rid of (summer) and how much heat you need to gain (winter) to be comfortable. The heat loads are broken down into dry heat (sensible by the thermostat) and wet heat (latent moisture/humidity). You can learn the amount and ratio of these two heat loads by perfoming a heat load calculation on the space. After you know the capacity of the equipment needed you can then start designing an efficient duct system to transfer the heat. I recommend you pay a consultant to do this part but if you want to DIY there are homeowner programs available.
Go here
http://www.michaelholigan.com/mhetv/...?page_number=5 Click on Aprilaire segment #9010 This will help you understand the main zoning concept. If you think this is something for you then we can talk in more detail about how it works.