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Your question of warm air rising is correct. If you had a gravity fed furnace of 100 years ago, I would be concerned. Today we use the forced air systems to level the playing field. Some thoughts to consider: First, the trunk lines and equipment will have to be sized to allow for the volume (read cubic feet of space, not square feet) and anticipated BTU requirements. Second, you will want to make sure and insulate any ducts in uninsulated areas. Flex at the end of the trunk lines will tend to restrict what flow is left that far from the equipment. The transitions in the trunk line, are better done in 45's than 90's. Up or down is not of particular consiquence.
I would really recommend some time with a duct person as being well spent. Get these plans underway, as you will want the home roughed in for ductwork as soon as the framing is getting done. And above all else, remember the return airs. Lot's of them. Especially from the more distant areas.
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